Benjamin French, Ph.D.

Dr. French received a PhD in Biostatistics from the University of Washington in June 2008 and joined the faculty of the University of Pennsylvania in August 2008. His research interests are focused on analytic methodology for longitudinal, clustered, and survival data. He is particularly interested in applying this methodology to quantify comparative effectiveness, evaluate the impact of policy interventions, and quantify prediction accuracy. Additional research interests include genetic epidemiology and design of randomized trials. His collaborative interests are focused on cardiovascular disease epidemiology and health economics. Dr. French is highly interested in the implementation of statistical methods and data analysis using R, particularly for reproducible research and effective visualizations.

Recent Presentations

Statistical Methods

  1. French B, Lumley T, Monks SA, Rice KM, Hindorff LA, Reiner AP, Psaty BM. Simple estimates of haplotype relative risks in case-control data. Genetic Epidemiology 2006; 30(6):485–494. Questions.
  2. French B, Heagerty PJ. Analysis of longitudinal data to evaluate a policy change. Statistics in Medicine 2008; 27(24):5005–5025.
  3. French B, Heagerty PJ. Marginal mark regression analysis of recurrent marked point process data. Biometrics 2009; 65(2):415–422.
  4. French B, Joo J, Geller NL, Kimmel SE, Rosenberg Y, Anderson JL, Gage BF, Johnson JA, Ellenberg JH. Statistical design of personalized medicine interventions: The Clarification of Optimal Anticoagulation through Genetics (COAG) trial. Trials 2010; 11:108.
  5. Joo J, Geller NL, French B, Kimmel SE, Rosenberg Y, Ellenberg JH. Prospective alpha allocation in the Clarification of Optimal Anticoagulation through Genetics (COAG) trial. Clinical Trials 2010; 7(5):597–604.
  6. French B, Farjah F, Flum DR, Heagerty PJ. A general framework for estimating volume-outcome associations from longitudinal data. Statistics in Medicine 2012; 31(4):366–382.
  7. French B, Lumley T, Cappola TP, Mitra N. Non-iterative, regression-based estimation of haplotype associations with censored survival outcomes. Statistical Applications in Genetics and Molecular Biology 2012; 11(3):4.
  8. French B, Saha-Chaudhuri P, Ky B, Cappola TP, Heagerty PJ. Development and evaluation of multi-marker risk scores for clinical prognosis. Statistical Methods in Medical Research 2012. Supplementary material.
  9. Tan KS, French B, Troxel AB. Regression modeling of longitudinal data with outcome-dependent observation times: Extensions and comparative evaluation. Statistics in Medicine 2014; 33(27):4770–4789.
  10. French B, Small DS, Novak J, Saulsgiver KA, Harhay MO, Asch DA, Volpp KG, Halpern SD. Preference-adaptive randomization in comparative effectiveness studies. Trials 2015; 16:99.

Statistical Software

  • French B, Lumley T. haplo.ccs: Estimate haplotype relative risks in case-control data. R package version 1.3.1.

Biomedical Applications

  1. Erickson TN, Devine EB, O'Young TS, Hanson LJ, French B, Brennan C. Effect of switching medically vulnerable patients with uncontrolled diabetes from isophane insulin human to insulin glargine. American Journal of Health-System Pharmacy 2006; 63(19):1862–1871.
  2. Dublin S, French B, Glazer NL, Wiggins KL, Lumley T, Psaty BM, Smith NL, Heckbert SR. Risk of new-onset atrial fibrillation in relation to body mass index. Archives of Internal Medicine 2006; 166(21):2322–2328.
  3. Glazer NL, Dublin S, Smith NL, French B, Jackson LA, Siscovick DS, Psaty BM, Heckbert SR. Newly detected atrial fibrillation and compliance with antithrombotic guidelines. Archives of Internal Medicine 2007; 167(3):246–252.
  4. Becker DJ, Gordon RY, Halbert SC, French B, Morris PB, Rader DJ. Red yeast rice for dyslipidemia in statin-intolerant patients: A randomized trial. Annals of Internal Medicine 2009; 150(12):830–839.
  5. Sutton RM, Maltese MR, Niles D, French B, Nishisaki A, Arbogast KB, Donoghue A, Berg RA, Helfaer MA, Nadkarni V. Quantitative analysis of chest compression interruptions during in-hospital resuscitation of older children and adolescents. Resuscitation 2009; 80(11):1259–1263.
  6. Halbert SC, French B, Gordon RY, Farrar JT, Schmitz K, Morris PB, Thompson PD, Rader DJ, Becker DJ. Tolerability of red yeast rice (2400 mg twice daily) versus pravastatin (20 mg twice daily) in patients with previous statin intolerance. American Journal of Cardiology 2010; 105(2):198–204.
  7. Khera AV, Cuchel M, de la Llera-Moya M, Rodrigues A, Burke MF, Jafri K, French B, Phillips JA, Mucksavage ML, Wilensky RL, Mohler ER, Rothblat GH, Rader DJ. Cholesterol efflux capacity, high-density lipoprotein function, and atherosclerosis. New England Journal of Medicine 2011; 364(2):127–135.
  8. Ky B, French B, McCloskey K, Rame JE, McIntosh E, Shahi P, Dries D, Tang WHW, Wu AH, Fang JC, Boxer R, Sweitzer NK, Levy W, Goldberg L, Jessup M, Cappola TP. High-sensitivity ST2 for prediction of adverse outcomes in chronic heart failure. Circulation Heart Failure 2011; 4(2):180–187.
  9. Goldberg DJ, French B, McBride MG, Marino BS, Mirarchi N, Hanna BD, Wernovsky G, Paridon SM, Rychik J. Impact of oral sildenafil on exercise performance in children and young adults after the Fontan operation: A randomized, double-blind, placebo-controlled, crossover trial. Circulation 2011; 123(11):1185–1193.
  10. Sutton RM, Niles D, Meaney PA, Aplenc R, French B, Abella BS, Lengetti EL, Berg RA, Helfaer MA, Nadkarni V. "Booster" training: Evaluation of instructor-led bedside cardiopulmonary resuscitation skill training and automated corrective feedback to improve cardiopulmonary resuscitation compliance of Pediatric Basic Life Support providers during simulated cardiac arrest. Pediatric Critical Care Medicine 2011; 12(3):e116–e121.
  11. Goldberg DS, French B, Thomasson A, Reddy KR, Halpern SD. Current trends in living donor liver transplantation for primary sclerosing cholangitis. Transplantation 2011; 91(10):1148–1152.
  12. Mohler ER, Zhang L, Medenilla E, Rogers W, French B, Bantly A, Moore JS, Huan Y, Murashima M, Berns JS. Effect of darbepoetin alfa on endothelial progenitor cells and vascular reactivity in chronic kidney disease. Vascular Medicine 2011; 16(3):183–189.
  13. Sutton RM, Niles D, Meaney PA, Aplenc R, French B, Abella BS, Lengetti EL, Berg RA, Helfaer MA, Nadkarni V. Low-dose, high-frequency CPR training improves skill retention of in-hospital pediatric providers. Pediatrics 2011; 128(1):e145–e151.
  14. Ky B, French B, Ruparel K, Sweitzer NK, Fang JC, Levy WC, Sawyer DB, Cappola TP. The vascular marker soluble fms-like tyrosine kinase 1 is associated with disease severity and adverse outcomes in chronic heart failure. Journal of the American College of Cardiology 2011; 58(4):386–394.
  15. McLeod L, French B, Dai D, Localio R, Keren R. Patient volume and quality of care for young children hospitalized with acute gastroenteritis. Archives of Pediatric and Adolescent Medicine 2011; 165(9):857–863.
  16. Goldberg D, French B, Thomasson A, Reddy KR, Halpern SD. Waitlist survival of patients with primary sclerosing cholangitis in the model for end-stage liver disease era. Liver Transplantation 2011; 17(11):1355–1363.
  17. Shan X, Quaile MP, Monk JK, French B, Cappola TP, Margulies KB. Differential expression of PDE5 in failing and non-failing human myocardium. Circulation Heart Failure 2012; 5(1):79–86.
  18. Gabler NB,French B, Strom BL, Liu Z, Palevsky HI, Taichman DB, Kawut SM, Halpern SD. Race and sex differences in response to endothelin receptor antagonists for pulmonary arterial hypertension. Chest 2012; 141(1):20–26.
  19. Ky B, French B, Levy WC, Sweitzer NK, Fang JC, Wu AH, Goldberg LR, Jessup M, Cappola TP. Multiple biomarkers for risk prediction in chronic heart failure. Circulation Heart Failure 2012; 5(2):183–190.
  20. Goldberg D, French B, Abt P, Feng S, Cameron AM. Increasing disparity in waitlist mortality rates with increased model for end-stage liver disease scores for candidates with hepatocellular carcinoma versus candidates without hepatocellular carcinoma. Liver Transplantation 2012; 18(4):434–443.
  21. Yehia BR, Long JA, Stearns CR, French B, Tebas P, Frank I. Impact of transitioning from HIV clinical trials to routine medical care on clinical outcomes and patient perceptions. AIDS Care 2012; 24(6):769–777.
  22. Goldberg DJ, French B, Szwast AL, McBride MG, Marino BS, Mirarchi N, Hanna BD, Wernovsky G, Paridon SM, Rychik J. Impact of sildenafil on echocardiographic indices of myocardial performance after the Fontan operation. Pediatric Cardiology 2012; 33(5):689–696.
  23. Gabler NB, French B, Strom BL, Palevsky HI, Taichman DB, Kawut SM, Halpern SD. Validation of 6-minute walk distance as a surrogate end point in pulmonary arterial hypertension trials. Circulation 2012; 126(3):349–356.
  24. Jenny NS, French B, Arnold AM, Strotmeyer ES, Cushman M, Chaves PH, Ding J, Fried LP, Kritchevsky SB, Rifkin DE, Sarnak MJ, Newman AB. Long-term assessment of inflammation and healthy aging in late life: The Cardiovascular Health Study All Stars. Journals of Gerontology Series A: Biological Sciences and Medical Sciences 2012; 67(9):970–976.
  25. deGoma EM, French B, Dunbar RL, Allison MA, Mohler ER, Budoff MJ. Intraindividual variability of C-reactive protein: The Multi-Ethnic Study of Atherosclerosis. Atherosclerosis 2012; 224(1):274–279.
  26. Zakai NA, French B, Arnold AM, Newman AB, Fried LF, Robbins J, Chaves P, Cushman M. Hemoglobin decline, function, and mortality in the elderly: The Cardiovascular Health Study. American Journal of Hematology 2013; 88(1):5–9.
  27. deGoma EM, Dunbar RL, Jacoby D, French B. Differences in absolute risk of cardiovascular events using risk-refinement tests: A systematic analysis of four cardiovascular risk equations. Atherosclerosis 2013; 227(1):172–177.
  28. Sutton RM, French B, Nishisaki A, Niles DE, Maltese MR, Boyle L, Stavland M, Eilevstjønn J, Arbogast KB, Berg RA, Nadkarni VM. American Heart Association cardiopulmonary resuscitation quality targets are associated with improved arterial blood pressure during pediatric cardiac arrest. Resuscitation 2013; 84(2):168–172.
  29. McLeod LM, Keren R, Gerber J,French B, Song L, Sampson NR, Flynn J, Dormans JP. Perioperative antibiotic use for spinal surgeries in US children's hospitals. Spine 2013; 38(7):609–616.
  30. Kurtzman N, Zhang L, French B, Jonas R, Bantley A, Rogers WT, Moore JS, Rickels MR, Mohler ER. Personalized cytomic assessment of vascular health: Evaluation of the vascular health profile in diabetes mellitus. Cytometry Part B 2013; 84(4):255–266.
  31. Goldberg D, French B, Trotter J, Shetty K, Schiano T, Reddy KR, Halpern SD. Underreporting of liver transplant waitlist removals due to death or clinical deterioration: Results at four major centers. Transplantation 2013; 96(2):211–216.
  32. Becker DJ, French B, Morris PB, Silvent E, Gordon RY. Phytosterols, red yeast rice, and lifestyle changes instead of statins: A randomized, double-blinded, placebo-controlled trial. American Heart Journal 2013; 166(1):187–196.
  33. deGoma EM, Davis M, Dunbar RL, Mohler ER, Greenland P, French B. Discordance between non-HDL-cholesterol and LDL-particle measurements: Results from the Multi-Ethnic Study of Atherosclerosis. Atherosclerosis 2013; 229(2):517–523.
  34. Florin TA, French B, Alpern ER, Zorc JJ, Shah SS. Variation in emergency department diagnostic testing and disposition outcomes in pneumonia. Pediatrics 2013; 132(2):237–244.
  35. Kimmel SE, French B, Anderson JL, Gage BF, Johnson JA, Rosenberg YD, Geller NL, Kasner SE, Eby CS, Joo J, Caldwell MD, Goldhaber SZ, Hart RG, Cifelli D, Madigan R, Brensinger CM, Goldberg S, Califf RM, Ellenberg JH. Rationale and design of the Clarification of Optimal Anticoagulation through Genetics trial. American Heart Journal 2013; 166(3):435–441.
  36. Ky B, French B, May Khan A, Plappert T, Wang A, Chirinos JA, Fang JC, Sweitzer NK, Borlaug BA, Kass DA, St John Sutton M, Cappola TP. Ventricular-arterial coupling, remodeling, and prognosis in chronic heart failure. Journal of the American College of Cardiology 2013; 62(13):1165–1172.
  37. Myers SR, Branas CC, French B, Nance ML, Kallan MJ, Wiebe DJ, Carr BG. Safety in numbers: Are major cities the safest places in the US? Annals of Emergency Medicine 2013; 62(4):408–418.
  38. Richardson K, Schoen M, French B, Umscheid CA, Mitchell MD, Arnold SE, Heidenreich PA, Rader DJ, deGoma EM. Statins and cognitive function: A systematic review. Annals of Internal Medicine 2013; 159(10):688–697.
  39. Goldberg DS, Makar G, Bittermann T, French B. Center variation in the use of nonstandardized model for end-stage liver disease exception points. Liver Transplantation 2013; 19(12):1330–1342.
  40. Baillie CA, VanZandbergen C, Tait G, Hanish A, Leas B, French B, Hanson W, Behta M, Umscheid CA. The readmission risk flag: Using the electronic health record to automatically identify patients at risk for 30-day readmission. Journal of Hospital Medicine 2013; 8(12):688–697.
  41. Kimmel SE, French B, Kasner SE, Johnson JA, Anderson JL, Gage BF, Rosenberg YD, Eby CS, Madigan RA, McBane RD, Abdel-Rahman SZ, Stevens SM, Yale S, Mohler ER, Fang MC, Shah V, Horenstein RB, Limdi NA, Muldowney AS, Gujral J, Delafontaine P, Desnick RJ, Ortel TL, Billett HH, Pendleton RC, Geller NL, Halperin JL, Goldhaber SZ, Caldwell MD, Califf RM, Ellenberg JH. A pharmacogenetic versus a clinical algorithm for warfarin dosing. New England Journal of Medicine 2013; 369(24):2283–2293.
  42. Sutton RM, Niles D, French B, Maltese MR, Leffelman J, Eilevstjønn J, Wolfe H, Nishisaki A, Meany PA, Berg RA, Nadkarni VM. First quantitative analysis of cardiopulmonary resuscitation quality during in-hospital cardiac arrests of young children. Resuscitation 2014; 85(1):70–74.
  43. Zhang KW, French B, May Khan A, Plappert T, Fang JC, Sweitzer NK, Borlaug BA, Chirinos JA, St John Sutton M, Cappola TP, Ky B. Strain improves risk prediction beyond ejection fraction in chronic systolic heart failure. Journal of the American Heart Association 2014; 3(1):e000550.
  44. Yehia BR, French B, Fleishman JA, Metlay JP, Berry SA, Korthuis PT, Agwu AL, Gebo KA. Retention in care is more strongly associated with viral suppression in HIV-infected patients with lower versus higher CD4 counts. Journal of Acquired Immune Deficiency Syndromes 2013; 65(3):333–339.
  45. Ky B, Putt M, Sawaya H, French B, Januzzi JL, Sebag IA, Plana JC, Cohen V, Banchs J, Carver JR, Wiegers SE, Martin RP, Picard MH, Gerszten RE, Halpern EF, Passeri J, Kuter I, Scherrer-Crosbie M. Early increases in multiple biomarkers predict subsequent cardiotoxicity in breast cancer patients treated with doxorubicin, taxanes, and trastuzumab. Journal of the American College of Cardiology 2014; 63(8):809–816.
  46. Goldberg DS, French B, Forde KA, Groenveld PW, Bittermann T, Backus L, Halpern SD, Kaplan DE. Association of distance From a transplant center with access to waitlist placement, receipt of liver transplantation, and survival among US veterans. Journal of the American Medical Association 2014; 311(12):1234–1243.
  47. Topjian AA, French B, Sutton RM, Conlon T, Nadkarni VM, Moler FW, Dean JM, Berg RA. Early post-resuscitation hypotension is associated with increased mortality following pediatric cardiac arrest. Critical Care Medicine 2014; 42(6):1518–1523.
  48. Basuray A, French B, Ky B, Vorovich E, Olt C, Sweitzer NK, Cappola TP, Fang JC. Heart failure with recovered ejection fraction: Clinical description, biomarkers, and outcomes. Circulation 2014; 129(23):2380–2387.
  49. Vorovich E, French B, Ky B, Goldberg L, Fang JC, Sweitzer NK, Cappola TP. Biomarker predictors of cardiac hospitalization in chronic heart failure: A recurrent event analysis. Journal of Cardiac Failure 2014; 20(8):569–576.
  50. Baillie CA, Epps M, Hanish A, Fishman NO, French B, Umscheid CA. Usability and impact of a computerized clinical decision support intervention designed to reduce urinary catheter utilization and catheter-associated urinary tract infections. Infection Control and Hospital Epidemiology 2014; 35(9):1147–1155.
  51. Sutton RM, French B, Niles DE, Donoghue A, Topjian AA, Nishisaki A, Leffelman J, Wolfe H, Berg RA, Nadkarni VM, Meaney PA. 2010 American Heart Association recommended compression depths during pediatric in-hospital resuscitations are associated with survival. Resuscitation 2014; 85(9):1179–1184.
  52. Friess SH, Sutton RM, French B, Bhalala U, Maltese MR, Naim MY, Bratinov G, Arciniegas Rodriguez S, Weiland TR, Garuccio M, Nadkarni VM, Becker LB, Berg RA. Hemodynamic directed CPR improves cerebral perfusion pressure and brain tissue oxygenation. Resuscitation 2014; 85(9):1298–1303.
  53. Yang Y-X, French B, Localio AR, Brensinger CM, Lewis JD. Minimal benefit of earlier-than-recommended repeat colonoscopy among US Medicare enrollees following a negative colonoscopy. Alimentary Pharmacology and Therapeutics 2014; 40(7):843–853.
  54. Goldberg DS, French B, Abt PL, Olthoff K, Shaked A. Superior survival using living donors and donor-recipient matching using a novel living donor risk index. Hepatology 2014; 60(5):1717–1726.
  55. Saloner B, Matone M, Kreider AR, Budeir MS, Miller D, Huang Y-S, Raghavan R, French B, Rubin D. Second-generation antipsychotic use among stimulant-using children, by organization of Medicaid mental health. Psychiatric Services 2014; 65(12):1458–1464.
  56. Umscheid CA, Betesh J, VanZandbergen C, Hanish A, Tait G, Mikkelsen ME, French B, Fuchs BD. Development, implementation, and impact of an automated early warning and response system for sepsis. Journal of Hospital Medicine 2015; 10(1):26–31.
  57. Finkelman BS, French B, Bershaw L, Kimmel SE. Factors affecting time to maintenance dose in patients initiating warfarin. Pharmacoepidemiology and Drug Safety 2015; 24(3):228–236.
  58. Barbieri JS, French B, Umscheid CA. Uptake and impact of a clinical diagnostic decision support tool at an academic medical center. Diagnosis 2015; 2(2):123–127.
  59. Halpern SD, French B, Small DS, Saulsgiver K, Harhay MO, Audrain-McGovern J, Loewenstein G, Brennan TA, Asch DA, Volpp KG. Randomized trial of four financial-incentive programs for smoking cessation. New England Journal of Medicine 2015; 372(22):2108–2117.
  60. Goldberg DS, French B, Abt PL, Gilroy R. Increasing the number of organ transplants in the United States by optimizing donor authorization rates. American Journal of Transplantation 2015; 15(8):2117–2125.
  61. Kasner SE, Wang L, French B, Messe SR, Horenstein R, Mohler ER, Muldowney JA, Ellenberg J, Kimmel SE. The impact of inpatient versus outpatient initiation on early warfarin dosing. American Journal of Cardiovascular Drugs 2015; 15(4):267–274.
  62. Wood JN, French B, Song L, Feudtner C. Evaluation for occult fractures in injured children. Pediatrics 2015; 136(2):232–240.
  63. McLeod L, French B, Flynn JM, Dormans JP, Keren R. Antifibrinolytic use and blood transfusions in pediatric scoliosis surgeries performed at US children's hospitals. Journal of Spinal Disorders and Techniques (in press).
  64. Wood JN, French B, Fromkin J, Fakeye O, Scribano PV, Letson MM, Makoroff KL, Feldman KW, Fabio A, Berger R. Association of pediatric abusive head trauma rates with macroeconomic indicators. Academic Pediatrics (in press).
  65. Chesnokova A, French B, Weibe D, Camenga DR, Yun K. The association between neighborhood-level smoking and individual smoking risk: Maternal smoking among Latina women in Pennsylvania. Public Health Reports (in press).
  66. Wong CA, Ford CA, French B, Rubin DM. Changes in young adult primary care under the Affordable Care Act. American Journal of Public Health (in press).
  67. Fong H-F, French B, Rubin DM, Wood JN. Mental health services for children and caregivers remaining at home after suspected maltreatment. Children and Youth Services Review (in press).