Wensheng Guo, Ph.D.

Dr. Guo joined the biostatistics faculty at the University of Pennsylvania in 1998, and was promoted to Professor of Biostatistics in 2010. He was elected as ASA fellow in 2010. His research interest is broad, including functional data analysis, time series analysis and joint modeling of longitudinal and time-to-event data. He is also interested in developing statistical methodology motivated by challenging real applications. His methodological research has been supported by several R01 grants from NIH.

Dr. Guo currently has two postdoctoral fellowships available on functional data analysis. The postdocs will develop methodology motivated by real clinical problems and apply these methods to large clinical datasets. Strong theoretical training and computing skills are required. Send CV and three letters to wguo@upenn.edu if interested.


1991 B.S. University of Science and Technology of China (USTC)

1994 M.S. University of Colorado (Biostatistics)

1998 Ph.D. University of Michigan (Biostatistics)

Awards and Honors

1998 ENAR Travel Award, Spring Meeting, Pittsburgh, PA
1999 McCabe Award, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA
2002 Teaching Award, Department of Biostatistics and Epidemiology, University of Pennsylvania
2009 Elected member of International Statistical Institute
2010 Elected ASA Fellow
2014 JASA Applications and Case Study Special Invited Presentation at JSM
2015 ASA Outstanding Statistical Application Award


Time series analysis
Functional models
Longitudinal data analysis
Nonparametric methods
Dimension reduction


  • Hormone secretion patterns and feedback relationship
  • Circadian rhythms
  • EEG and EKG data
  • Biomarkers
  • Imaging and spatial data
  • Kidney and liver transplant data
  • Alternative medicine


  • Guo, W. , Wang, Y. and Brown, M.B. (1999), "A signal extraction approach to modeling hormone time series with pulses and a changing baseline." Journal of the American Statistical Association. 94(447): 746-756.
  • Guo, W. (2002), "Functional mixed effects models". Biometrics. 58: 121-128. (Software "SAS Macro fmixed" By Liu and Guo, 2011)
  • Guo, W., Dai, M., Ombao, H and von Sachs, R. (2003), "Smoothing spline ANOVA for time-dependent spectral analysis". Journal of the American Statistical Association. 98(3): 643-652.
  • Dai, M. and Guo, W. (2004) "Multivariate spectral analysis using Cholesky decomposition". Biometrika 91(3), 629-643.
  • Guo, W., Ratcliffe, S.J. and Ten Have, T.R.. (2004). "A Random Pattern-Mixture Model for Longitudinal Data with Dropouts." Journal of the American Statistical Association 99(4), 929-937.
  • Ombao, H.C., von Sachs, R.and Guo, W. (2005) The SLEX Analysis of Multivariate Non-Stationary Time Series. Journal of the American Statistical Association, 100, 519-531.
  • Cui, X., Guo, W., Lin, L. and Zhu, L. (2009): Covariate-adjusted nonlinear regression. Annals of Statistics 37(4): 1839-1870.
  • Krafty, RT, Hall, M. and Guo, W. (2011) “Functional mixed effects spectral analysis” Biometrika 98(3): 583-598.
  • Liu, Z, Cappola, AR, Crofford, LJ, Guo W. (2014) Modeling Bivariate Longitudinal Hormone Profiles by Hierarchical State Space Models. Journal of the American Statistical Association 109(505): 108-118.
  • Wierzbicki, MR, Guo, LB, Du, QT, Guo, W. (2014) Sparse Semiparametric Nonlinear Model with Application to Chromatographic Fingerprints (with discussions). Journal of the American Statistical Association. 109(508): 1339-1354.
  • Xu K, Guo W, Xiong M, Zhu L and Jin L(2016) An estimating equation approach to dimension reduction for longitudinal data. Biometrika 103 (1), 189-203.


  • Li Qin (2004) Assistant Professor at Fred Hutchinson Cancer Research Center/ University of Washington
  • Robert T. Krafty (2007) Assistant Professor at Department of Statistics, University of Pittsburgh
  • Angelo Elmi (2009) (Co-advised with Dr. Sarah Ratcliffe) Assistant Professor at Department of Biostatistics, George Washington University
  • Ziyue Liu (2010) Assistant Professor at Department of Biostatistics, Indiana University
  • Chengcheng Liu (2011) Senior statistician, Merck.& Co.
  • Michael Wierzbicki (2013) Statistician, EMMES, Co.


  • Sarah J. Ractcliffe (2000-2002, joint with Dr. Thomas Ten Have). Associate Professor at University of Pennsylvania.
  • Ming Dai (2000-2004). Assistant Professor at University of North Carolina at Charlotte.
  • Ying Yang (2002-2004). Professor at Tsinghua University in China.

Contact Information

Dr. Wensheng Guo
Center for Clinical Epidemiology and Biostatistics
University of Pennsylvania School of Medicine
613 Blockley Hall
423 Guardian Drive
Philadelphia, PA 19104-6021
wguo at mail.med.upenn.edu