Pamela Shaw, Ph.D.

Dr. Shaw's research interests include methodology to address covariate and outcome measurement error, the evaluation of diagnostic tests, and design of medical studies. She has a particular interest in the use of biomarker studies to calibrate exposure measurements in the fields of nutritional and physical activity epidemiology and environmental health. More recently she has developed a novel rank test to evaluate a composite survival outcome in the presence of interval censoring. She has continued collaborations in a variety of epidemiologic and clinical studies, with a focus on infectious and chronic disease.

Recent Presentations

  1. A novel rank test for bivariate outcomes when one is a surrogate. 59th World Statistics Congress of the International Statistical Institute. August 2013.
  2. Methods of analysis for failure time data that adjust for errors in survival outcomes revealed by audits. American Statistical Association Joint Statistical Meeting. August 2013.
  3. A randomized delayed start trial of linezolid in patients with extensively drug-resistent tuberculosis: Issues in design and analysis. Harvard School of Public Health Pharmaceutical & Regulatory Sciences Workshop. May 2013.
  4. A novel rank test for a time-to-event outcome that incorporates information on a surrogate event. New York University School of Medicine, Division of Biostatistics. December 2012.

Statistical Methodology

  1. Shaw PA and Proschan MA. Null but not void: Considerations for hypothesis testing. Statistics in Medicine, 2013, 32(2): 196-205.
  2. Shepherd B, Shaw PA and Dodd L. Using audit Information to adjust parameter estimates for data errors in clinical trials. Clinical Trials, 2012 Dec; 9(6): 721-729.
  3. Shaw PA, Prentice, RL. Hazard Ratio Estimation for Biomarker-Calibrated Dietary Exposures. Biometrics, 2012 Jun; 68(2): 397-407.
  4. Proschan MA, Shaw PA. Asymptotics of Bonferroni for dependent normal test statistics. Statistics and Probability Letters, 2011 Jul; 81: 739-748.
  5. Lumley T, Shaw PA, Dai JY. Connections between survey calibration estimators and semiparametric models for incomplete data. International Statistical Review, 2011; 79(2): 200–220.
  6. Shaw PA, Pepe MS, Alonzo TA, Etzioni, R. Methods for assessing improvement in specificity when a biomarker is combined with a standard screening test. Statistics of Biopharmaceutical Research, 2009 Feb 1; 1(1): 18-25.

Statistical Software

  • Fay MP, Shaw PA. Exact and asymptotic weighted logrank tests for interval censored data: the interval R package. Journal of Statistical Software, 2010 Aug; 36 (2): 1-34.

Applications

  1. Lee M, Lee J, Carroll MW, Choi H, Min S, Song T, Via LE, Goldfeder LC, Kang E, Jin B, Park H, Kwak H, Kim H, Heon HS, Jeong I, Joh JS, Chen RY, Olivier KN, Shaw PA, Follmann D, Song SD, Lee JK, Lee DH, Kim CT, Dartois V, Park SK, Cho SN, Barry CE. Linezolid for Treatment of Chronic Extensively Drug-Resistant Tuberculosis. New England Journal of Medicine, 2012 Oct 18; 367(16):1508-1518.
  2. Greenberg DE, Shoffner AR, Marshall-Batty KR, Arora K, Zhao M, Martin R, Ding L, Hammer CH, Shaw PA, Kuhns DB, Malech HL, Gallin JI, Zaramber KA, Holland SM. Serologic Reactivity to the Emerging Pathogen Granulibacter bethesdensis. Journal of Infectious Diseases, 2012 Sep 15; 206(6):943-51.
  3. Browne SK, Burbelo PD, Chetchotisakd P, Suputtamongkol Y, Kiertiburanakul S, Shaw PA, Kirk JL, Jutivorakool K, Zaman R, Ding L, Hsu AP, Patel SY, Olivier KN, Lulitanond V, Moootskikapun P, Anunnatsiri, S, Angkasekwinai N, Sathapatayavongs B, Hsueh P, Shieh C, Brown MR, Thongnopppakhun W, Claypool R, Sampaio EP, Thepthai C, Waywa D, Dacombe C, Reizes Y, Zelazny AM, Saleeb P, Rosen L, Allen M, Iadarola M, Holland SM. Adult onset immunodeficiency in Thailand and Taiwan. New England Journal of Medicine, 2012 Aug 23;367(8):725-34.
  4. Carroll MW, Lee SY, Lee M, Cai Y, Hallahan CW, Shaw PA, Min JH, Goldfeder L, Kang HS, Hwang S, Park HM, Kang E, Jin B, Park HE, Min S, Park SK, Via LE, Barry CE. The Frequency of Adverse Reactions to First- and Second-line Anti-tuberculosis Chemotherapy in Korean patients. The International Journal of Tuberculosis and Lung Disease, 2012 Jul;16(7):961-6.
  5. Zarember KA, Marshall-Batty KR, Cruz AR, Chu J, Fenster ME, Shoffner AR, Rogge LS, Whitney AR, Czapiga M, Song HH, Shaw PA, Nagashima K, Malech HL, DeLeo FR, Holland SM, Gallin JI, Greenberg DE. Innate immunity against Granulibacter bethesdensis, an emerging Gram-negative bacterial pathogen, Infection and Immunity, 2012 Mar; 80 (3) 975-981.
  6. Hsu AP, Dowdel KC, Davis J, Niemela JE, Anderson SM, Shaw PA, Rao VK, Puck JM. Autoimmune Lymphoproliferative Syndrome due to FAS mutations outside the signal transducing death domain: Molecular mechanisms and clinical penetrance. Genetics in Medicine, 2012 Jan; 14(1) 81-89.
  7. Freeman AF, Mannino EA, Shaw PA, Davis J, Hsu AP, Welch P, Matta JR, Hadigan C, Pettigrew RI, Holland SM, Gharib AM. Coronary artery abnormalities in hyper IgE syndrome. Journal of Clinical Immunology, 2011 Jun; 31: 337-45.
  8. Heimall J, Davis, J, Shaw PA, Hsu A, Gu W, Welch P, Holland SM, Freeman AF. Paucity of genotype-phenotype correlations in STAT3 mutation positive hyper IgE syndrome. Clinical Immunology, 2011 Apr; 139:75-84.
  9. Prevots DR, Shaw PA Strickland D, Jackson L A, Raebel M A, Biosky MA, Montes de Oca R, Shea YR, Seltz AE, Holland SM Olivier KN. Nontuberculous mycobacterial lung disease prevalence at four integrated health care delivery systems. American Journal of Respiratory Critical Care Medicine, 2010 Oct 1; 182 (7): 970-6.
  10. Shaw PA Combination versus monotherapy for septic shock patients [Commentary]. Critical Care Medicine, 2010 Sep; 38 (9): 1905-6.
  11. Komati S, Shaw PA, Stubbs N, Mathibedi MJ, Malan L, Metcalf JA, Masur H, Hassim S. Tuberculosis risk factors and mortality for HIV infected persons receiving antiretroviral therapy in South Africa. AIDS, 2010 Jul 31; 24 (12): 1849-55.
  12. Greenberg DE, Marshall-Batty KR, Brinster LR, Zarember KA, Shaw PA, Mellbye BL, Iversen PL, Holland SM, and Geller BL. Antisense phosphorodiamidate morpholino oligomers targeted to an essential gene inhibit Burkholderia cepacia complex. Journal of Infectious Diseases, 2010 Jun; 201 (12): 1822-30.
  13. Hassim S, Shaw PA, Sangweni P, Malan L, Ntshani E, Mathibedi MJ, Stubbs N, Metcalf JA, Eckes R, Masur H, Komati S. Active sputum monitoring detects substantial rate of multi-drug resistant tuberculosis (MDR-TB) in an HIV-infected population in South Africa. Clinical Infectious Diseases, 2010 Apr 1; 50(7): 1053-9.
  14. Marques A, Shaw P, Schmid CH, Steere A, Kaplan RF, Hassett A, Shapiro E, Wormser GP. Re: A randomized, placebo-controlled trial of repeated IV antibiotic therapy for Lyme encephalopathy. Prolonged Lyme disease treatment: enough is enough [Commentary]. Neurology, 2009 Jan 27;72 (4):383-4.
  15. Prentice RL, Shaw PA, Bingham S A, Beresford SA, Caan B, Neuhouser ML, Patterson RE, Stefanick ML, Satterfield S, Thomson CA, Snetselaar L, Thomas A, Tinker LF. Biomarker-calibrated energy and protein consumption and increased cancer risk among postmenopausal women. American Journal of Epidemiology, 2009 Apr 15;169(8):977-89.
  16. Zonios DI, Falloon J, Bennett, JE, Shaw PA, Chaitt D, Baseler MW, Adelsberger JW, Metcalf JA, Polis MA, Kovacs SJ, Kovacs JA, Davey RT, Lane HC, Masur H, and Sereti I. Idiopathic CD4+ lymphocytopenia: natural history and prognostic factors. Blood, 2008 Jul 15; 112 (2): 287-94.
  17. Neuhouser ML, Tinker L, Shaw PA, Schoeller D, Bingham SA, Van Horn L, Beresford SA, Caan B, Thomson C, Satterfield S, Kuller L, Heiss G, Smit E, Sarto G, Ockene J, Stefanick ML, Assaf A, Runswick S and Prentice RL. Use of recovery biomarkers to calibrate nutrient consumption self-reports in the Women’s Health Initiative. American Journal of Epidemiology, 2008 May 15; 167 (10): 1247-59.
  18. Jewett MW, Lawrence K, Bestor AC, Tilly K, Grimm D, Shaw PA, VanRaden M, Gherardini F, Rosa P A. The critical role of linear plasmid lp36 in the infection cycle of borrelia burgdorferi. Molecular Microbiology, 2007 Jun; 64 (5):1358-74.
  19. Etzioni R, Howlader N, Shaw PA, Ankerst DP, Penson DF, Goodman PJ, Thompson IM. Long-term effects of finasteride on PSA Levels: results from the Prostate Cancer Prevention Trial. Journal of Urology 2005 Sep; 174(3):877–81.
  20. Shaw PA, Etzioni R, Zeliadt S, Mariotto A, Karnofski K, Penson D, Weiss N, Feuer E. Ecologic study of PSA screening and prostate cancer mortality in nine geographic areas of the US. American Journal of Epidemiology, 2004; 160(11):1059–1069.
  21. Etzioni R, Berry KM, Legler JM, Shaw PA. Prostate-specific antigen testing in black and white men: an analysis of Medicare claims from 1991-1998. Urology, 2002 Feb; 59(2):251–5.
  22. Zabel R, Anderson J, Shaw P. A multiple reach model to describe the migratory behavior of Snake River yearling chinook salmon. Canadian Journal of Fisheries and Aquatic Sciences, 1998; 55(3): 658–667.

Book Chapters and other non-Refereed Scholarly Publications

  1. Shaw PA, Lee Johnson L, Borkowf CB. Issues in Randomization. In: Gallin JI, Ognibene FP. Principles and Practice of Clinical Research. Elsevier Inc.: Academic Press; 2012. p. 243–253.
  2. Lee Johnson L, Borkowf CB, Shaw PA. Hypothesis Testing. In: Gallin JI, Ognibene FP. Principles and Practice of Clinical Research. Elsevier Inc.: Academic Press; 2012. p. 255–270.
  3. Shaw PA, Lee Johnson L, Proschan MA. Intermediate Topics in Biostatistics. In: Gallin JI, Ognibene FP. Principles and Practice of Clinical Research. Elsevier Inc.: Academic Press; 2012. p. 295–320.
  4. Shaw P A. The appropriate use of statistics in biological sciences. The American Association of Immunologists Newsletter, 2010, March/April.
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