Matthew W Bryan, Ph.D.

Dr. Bryan’s statistical research focuses on longitudinal methods for comparing rates of change. This methodology can be applied to many scientific areas, including studies of childhood growth, clinical trials with longitudinally measured outcomes, and tumor growth. For example, these methods were used to evaluate the possible association between early antibiotic exposure and weight gain in children. Other areas of research interest include methodology for multivariate longitudinal data and non-parametric smooth function estimation via penalized splines. His collaborative work focuses on studies in pediatrics and, in particular, on studies of infant growth, infectious disease, and mental health. He is a faculty member of the Pediatrics Biostatistics Section within the Division of Biostatistics, which centers on collaborations at the Children’s Hospital of Philadelphia (CHOP). He joined the biostatistics faculty in August 2013.


  • Nephew LD, Goldberg D, Lewis JD, Abt P, Bryan M, Forde KA: Exception Points and Body Size Contribute to Gender Disparity in Liver Transplantation. Clinical Gastroenterology Hepatology March 2017.
  • Handy LK, Bryan M, Gerber JS, Zaoutis T, Feemster KA: Variability in Antibiotic Prescribing for Community-Acquired Pneumonia. Pediatrics March 2017.
  • Gold LS, Bryan M, Comstock BA, Bresnahan BW, Deyo RA, Nedeljkovic SS, Nerenz DR, Heagerty P, Jarvik JG: Associations Between Relative Value Units and Patient-Reported Back Pain and Disability. Gerontology and Geriatric Medicine January 2017.
  • Bryan M, Heagerty P: Multivariate Analysis of Longitudinal Rates of Change. Statistics in Medicine 35(28): 5117-5134, December 2016.
  • Shah SS, Srivastava R, Wu S, Colvin JD, Williams DJ, Rangel S, Samady W, Rao S, Miller C, Cross C, Clohessy C, Hall M, Localio R, Bryan M, Wu G, Keren R: Intravenous Versus Oral Antibiotics for Postdischarge Treatment of Complicated Pneumonia. Pediatrics 138(6), December 2016.
  • Samuels-Kalow ME, Bryan MW, Shaw KN: Predicting subsequent high-frequency, low-acuity utilization of the pediatric emergency department.Academic Pediatrics November 2016.
  • Gerber JS, Bryan M, Stallings VA: Early Antibiotic Exposure and Childhood Weight Gain--Reply. JAMA 316(5): 542, August 2016.
  • Rangel SJ, Anderson BR, Srivastava R, Shah SS, Ishimine P, Srinivasan M, Bryan M, Gong W, Hall M, Localio R, Luan X, Anandalwar S, Keren R: Intravenous Versus Oral Antibiotics for the Prevention of Treatment Failure in Children With Complicated Appendicitis: Has the Abandonment of Peripherally Inserted Catheters Been Justified? Annals of Surgery July 2016.
  • Gerber JS, Bryan M, Ross RK, Daymont C, Parks EP, Localio AR, Grundmeier RW, Stallings VA, Zaoutis TE: Antibiotic Exposure During the First 6 Months of Life and Weight Gain During Childhood. JAMA 315(12): 22-29, March 2016.
  • Vendetti N, Bryan M, Zaoutis TE, Damianos A, Fisher BT: Comparative effectiveness of fungicidal vs. fungistatic therapies for the treatment of paediatric candidaemia. Mycoses 59(3): 173-178, March 2016.